| Tuesday,
September 11, 2007 |
| 7:00 A.M.
– 5:00 P.M. |
Registration |
Monterey Conf. Ctr,
Steinbeck Lobby |
| 7:00 A.M.
– 8:00 A.M. |
Continental Breakfast
|
Monterey Conf. Ctr,
Steinbeck Lobby |
| 8:00
A.M. – 8:15 A.M. |
Opening
Remarks
Dr. C.J. Miller, Leader, Virology & Immunology Unit
California National Primate Research Center
|
Steinbeck Forum |
| 8:15
A.M. – 9:00 A.M. |
Keynote Address:
Dr. Julie Overbaugh
Fred Hutchison Cancer Research Center
Seattle, Washington
|
Steinbeck Forum |
| 9:00 A.M.
– 10:30 A.M. |
Scientific Session
1: Virology (Part I)
Chair: Dr. Preston Marx
Tulane National Primate Research Center
Co-Chair: Dr. Murray Gardner
Center for Comparative Medicine
|
Steinbeck Forum |
| 9:00 A.M.
– 9:30 A.M. |
Presentation by Session Chair
Dr. Preston Marx
Tulane National Primate Research Center
25 Years Studying SIV Cross-Species Transmission:
Rapid Progress, Slow Progress and No Progress At All.
|
Steinbeck Forum |
| 9:30 A.M.
– 9:50 A.M. |
Abstract 1 —
Antibody-mediated neutralization of SIVmac239
*Shuji Sato, Hannah Sanford, Andy Lauer, Eun Hyuk Chang, Welkin Johnson.
|
Steinbeck Forum |
| 9:50 A.M.
– 10:10 A.M. |
Abstract 2 —
Pathogenic SIV challenge virus is responsible for uncontrolled viral replication in all tissues in SHIV immunized rhesus macaques.
*Mars Stone, Linda Fritts, Christopher Miller.
|
Steinbeck Forum |
| 10:10 A.M.
– 10:30 A.M. |
Abstract 3 —
SIVagm mainly replicates in short-lived cels during primary and chronic non-pathogenic infection of African green monkeys.
*Ivona Pandrea, Ruy Ribeiro, Rajeev Gautam, Melissa Pattison, Mary Barnes, Chris Monjure, Thaidra Gauffin, Crystal Stoulig, Guido Silvestri, Preston Marx, Michael Miller, Alan Perelson, Cristian Apetrei.
|
Steinbeck Forum |
| 10:30 A.M.
– 11:00 A.M. |
Morning Break
|
|
| 11:00
A.M. – 12:00
P.M. |
Scientific Session
1: Virology (Part II)
|
Steinbeck Forum |
| 11:00 A.M. – 11:20 A.M. |
Abstract 4 —
Control of viremia and preservation of intestinal CD4+ T cells in SHIVsf162p3 infected macaques intravenously challenged with pathogenic SIVmac251.
*Bapi Pahar, Xiaolei Wang, Michael Piatek, Jr., Jeffrey D. Lifson, Binhua Ling, Ronald S. Veazey.
|
Steinbeck Forum |
| 11:20 A.M. – 11:40 A.M. |
Abstract 5 —
Efficacy of deglycosylation mutants derived from SIVmac239 as live attenuated vaccines against SIVsmE543; A heterologous challenge model for vaccine against naturally occurred HIV diversity.
*Chie Sugimoto, Yasuo Suzuki, Yoshiyuki Nagai, Vanessa Hirsch, Naoki Yamamoto, Kazuyasu Mori.
|
Steinbeck Forum |
| 11:40 A.M. – 12:00 P.M. |
Abstract 6 —
Differential Pathogenicity of SHIVSF162 P4 Infection in pig-tailed and rhesus macaques.
Patricia Polacino, Kay Larsen, Lindsey Galmin, John Suschak, Zane Kraft, Leo Stamatatos, David Anderson, Ranajit Pal, Kristen Bost, Christopher J. Miller, *Shiu-Lok Hu.
|
Steinbeck Forum |
| 12:00 P.M.
– 12:15 P.M. |
Invited Talk —
Journal of Medical Primatology |
Steinbeck Forum |
| 12:15 P.M.
– 2:00 P.M. |
Lunch |
Portola Plaza |
| 2:00
P.M. – 3:30 P.M. |
Scientific Session
2: Immunology (Part I)
Chair: Dr. Amitinder Kaur
New England Primate Research Center
Co-Chair: Dr. Kristina Abel
California National Primate Research Center
|
Steinbeck Forum |
| 2:00 P.M. – 2:30 P.M. |
Presentation by Session Chair
Amitinder Kaur
New England Primate Research Center
CD4+ T lymphocytes and immune control of CMV:
lessons for AIDS pathogenesis
|
Steinbeck Forum |
| 2:30 P.M. – 2:50 P.M. |
Abstract 7 —
PD-1: a marker for activated or exhausted T cells?
*Nadine C. Salisch, Jacqueline Gillis, Paul Johnson.
|
Steinbeck Forum |
| 2:50 P.M.
– 3:10 P.M. |
Abstract 8 —
Correlates of B and T cell immune responses in non-pathogenic SIVagm infection in African green monkeys (AGMs)
*David Favre, Z. Cabrilo, J.M. Lozano Reina, A. Faye, M.T. Nguyere, T. Ka, Christopher Miller, Francoise Barré-Sinoussi, Michaela Müller-Trutwin, Ousmane Diop, Joseph McCune.
|
Steinbeck Forum |
| 3:10 P.M.
– 3:30 P.M. |
Abstract 9 —
Control of SHIV-SF162P3 viremia and neutralizing antibody development in macaque newborns in the presence of passive IgG.
*Cherie T. Ng, William F. Sutton, Patrick Delio, LaRene Kuller, David Anderson, Pushpa Jayaraman, Dennis Burton, Nancy L. Haigwood.
|
Steinbeck Forum |
| 3:30 P.M.
– 4:00 P.M. |
Afternoon Break
|
|
| 4:00
P.M. – 5:20 P.M. |
Scientific Session
2: Immunology (Part II)
|
Steinbeck Forum |
| 4:00 P.M. – 4:20 P.M. |
Abstract 10 —
Changes in chemokine networks reshape lyphmoid tissue environments during SIV infection: an expanding model of disease mechanisms
*Todd A. Reinhart, Yongjun Sui, Shulin Qin, Beth A. Fallert, James E. Pease, Patrick M. Tarwater, Michael A. Murphey-Corb.
|
Steinbeck Forum |
| 4:20 P.M. – 4:40 P.M. |
Abstract 11 —
Preservation of a subset of SIV-specific CD4+ T cells with central memory markers correlates to control of viremia in SIVmac251 infected macaques
*Agneta von Gegerfelt, Antonio Valentin, Vainav Patel, Candido Alicea, Koen K.A.Van Rompay, Marta L. Marthas, George N. Pavlakis, Barbara K. Felber.
|
Steinbeck Forum |
| 4:40 P.M. – 5:00 P.M. |
Abstract 12 —
Role of Cellular Immune Responses in Controlling Viral Replication During Infection with Primary SIVsmm Isolates of Rhesus Macaques.
*Rajeev Gautam, Ivona Pandrea, Melissa Kasheta, Erin Ribka, Thaidra Gaufin, Melissa Pattison, Mary Barnes, Preston A. Marx, David Montefiori, Amitinder Kaur, Cristian Apetrei.
|
Steinbeck Forum |
| 5:00 P.M. – 5:20 P.M. |
Abstract 13 —
Killing kinetics of SIV-specific CD8+ T cells: implications for HIV vaccine strategies.
*Stephen J. Kent, Miranda Z. Smith, Andrew G. Brooks, Damian F.J. Purcell, Bartek Zuber, Erik Rollman.
|
Steinbeck Forum |
| 7:00 P.M.
– 9:30 P.M. |
Reception and Poster
Session
|
Serra Ballroom |
| |
|
|
| Wednesday,
September 12, 2007 |
| 7:00 A.M.
– 5:00 P.M. |
Registration Continues |
Monterey Conf. Ctr,
Steinbeck Lobby |
| 7:30 A.M.
– 8:30 A.M. |
Continental Breakfast |
Monterey Conf. Ctr,
Steinbeck Lobby |
| 8:30
A.M. – 10:00 A.M. |
Scientific Session
3: Pathogenesis (Part I)
Chair: Dr. Guido Silvestri
Hospital of the University of Pennsylvania
Co-Chair: Dr. Christopher Miller
California National Primate Research Center
|
Steinbeck Forum |
| 8:30 A.M. – 9:00 A.M. |
Presentation by Session Chair
Guido Silvestri
Hospital of the University of Pennsylvania
AIDS pathogenesis: a tale of two monkeys. |
Steinbeck Forum |
| 9:00 A.M. – 9:20 A.M. |
Abstract 14 —
Acute Intestinal CD4+ T Cell Depletion Is Not Predictive of SIV Virulence.
*Cristian Apetrei, Rajeev Gautam, Ruy M. Ribeiro, Thaidra Gaufin, Melissa Pattison, Crystal Stoulig, Mary Barnes, Christopher Monjure, P. Aye, G. Silvestri, A.A. Lackner, P.A. Marx, A. S. Perelson, I. Pandrea.
|
Steinbeck Forum |
| 9:20 A.M. – 9:40 A.M. |
Abstract 15 —
Differential CD4+ and CD8+ T lymphocyte apoptosis during acute SIV infection in sooty mangabeys and rhesus macaques.
*Mareike Meythaler, Amanda Martinot, Sarah Pryputniewicz, Zichun Wang, Melissa Kasheta, Binhua Ling, Preston A. Marx, Shawn O’Neil, Amitinder Kaur.
|
Steinbeck Forum |
| 9:40 A.M. – 10:00 A.M. |
Abstract 16 —
Association of CCL25 and CXCL12 and apoptosis of cells in lymphoid tissues of cynomolgus macaque during SIV infection.
*Shulin Qin, Yongjun Sui, Beth A. Fallert, Michael A. Murphy-Corb, Patrick M. Tarwater, Denise E. Kirschner, Todd A. Reinhart.
|
Steinbeck Forum |
| 10:00 A.M.
– 10:30 A.M. |
Morning Break
|
|
| 10:30
A.M. – 11:50
A.M. |
Scientific Session
3: Pathogenesis (Part II)
|
Steinbeck Forum |
| 10:30 A.M. – 10:50 A.M. |
Abstract 17 —
Regulatory T cells suppress SIV-specific CD4+T, but not CD8+T cell responses in infant macaques - implication for SIV pathogenesis.
*Kristina Abel, Dennis Hartigan-O’Connor, Joseph M. McCune
|
Steinbeck Forum |
| 10:50 A.M. – 11:10 A.M. |
Abstract 18 —
Virus Burden and Distribution in Lymph Nodes During Acute SIVsmm Infection of Sooty Mangabey versus Pigtailed Macaque Monkeys.
*Amanda J. Martinot, Douglas R. Pauley, Mareike Meythaler, Heather Knight, Dennis G. Walsh, Daniel C. Anderson, Amitinder Kaur, Shawn P. O’Neil.
|
Steinbeck Forum |
| 11:10 A.M. – 11:30 A.M. |
Abstract 19 —
Pathogenesis of the oral mucosa in primary SIV infection.
*Michael George, David Verhoeven, Sumathi Sandaran, Elizabeth Reay, Satya Dandekar.
|
Steinbeck Forum |
| 11:30 A.M. – 11:50 A.M. |
Abstract 20 —
SIV in the male genital tract: kinetic of infection, nature of target cells and immune responses.
*Frederic Martinon, Rein Sikut, Julie Morin, Isabelle Picq, Ioana Stanescu, Roger Le Grand.
|
Steinbeck Forum |
| 11:50
A.M. – 1:30
P.M. |
Lunch |
|
| 1:30
P.M. – 3:00 P.M. |
Scientific Session
4: Vaccines (Part I)
Chair: Dr. Marjorie Robert-Guroff
National Cancer Institute
Co-Chair: Dr. Marta Marthas
California National Primate Research Center
|
Steinbeck Forum |
| 1:30 P.M. – 2:00 P.M. |
Presentation by Session Chair
Marjorie Robert-Guroff
National Cancer Institute
|
Steinbeck Forum |
| 2:00 P.M. – 2:20 P.M. |
Abstract 21—
Live-attenuated lentivirus immunization mediated protection of rhesus macaques from intravaginal SIV challenge is associated with survival and polyfunctional capacity of SIV-specific CD8+ T cell in the genital tract.
*Meritxell Genescà, Kristen Bost, Yichuan Wang, Barinderpaul Chohan, Michael B. McChesney, Christopher J. Miller.
|
Steinbeck Forum |
| 2:20 P.M. – 2:40 P.M. |
Abstract 22 —
Vaccination with Simian Immunodeficiency Virus (SIV) Gag-Pol and Env Recombinants of Modified Vaccinia Virus Ankara (MVA) Preserves CD4 Memory T Cells after SIVsmE660 Challenge.
*Ilnour Ourmanov, Takeo Kuwata, Charles R. Brown, Simoy Goldstein, Vanessa M. Hirsch.
|
Steinbeck Forum |
| 2:40 P.M. – 3:00 P.M. |
Abstract 23 —
Targeting the CTLA-4 co-stimulatory signaling pathway using blocking antibodies induces robust SIV-specific CD8+ T-cell proliferation following DNA vaccination and reduces PD-1 expression on antigen-specific proliferating cells.
*David A. Hokey, Lauren Hirao, Jian Yan, Jean D. Boyer, Anlan Dai, Maria N. Jure-Kunkel, David B. Weiner.
|
Steinbeck Forum |
| 3:00 P.M.
– 3:30 P.M. |
Afternoon Break
|
|
| 3:30
P.M. – 4:50 P.M. |
Scientific Session
4: Vaccines (Part II)
|
Steinbeck Forum |
| 3:30 P.M. – 3:50 P.M. |
Abstract 24 —
Immunogenicity of different prime-boost regimens of replication-defective herpes simplex virus (HSVd106) vector-based SIV vaccines in rhesus macaques.
*Kenneth S. Chan, Sarah Pryputniewicz, Melissa Kasheta, Hannah B. Sanford, Eeva Broberg, Margherita Rosati, Michael Piatak, Jeffrey D. Lifson, George N. Pavlakis, Barbara K. Felber, Ronald C. Desrosiers, David M. Knipe, Amitinder Kaur.
|
Steinbeck Forum |
| 3:50 P.M. – 4:10 P.M. |
Abstract 25 —
Induction of local and systemic SIV-specific T cell responses by a VSV/MVA-SIV vaccine regimen cannot prevent rapid SIV dissemination after oral infection in infant macaques.
*Kristina Abel, Marta M. Marthas, Koen K. Van Rompay, Jack K. Rose, Patricia Earl, Joseph Moore.
|
Steinbeck Forum |
| 4:10 P.M. – 4:30 P.M. |
Abstract 26 —
SHIV89.6 Live Attenuated Vaccine Protection against Gut CD4+ T Cell Depletion and Intestinal Epithelial Cell Apoptosis.
*Q. Li, Z-M. Ma, L. Duan, M. Stone, M. Zupancic, C. Reilly, C. Miller, A.T. Haase.
|
Steinbeck Forum |
| 4:30 P.M. – 4:50 P.M. |
Abstract 27 —
Microarray comparisons show significant differences to treatment groups prior to challenge in a vaccine trial of replicating Ad-HIV/SIV recombinants alone or with HIV89.6P Env boosts.
*Robert E. Palermo, L. Jean Patterson, Lauri Aicher, Marjorie Robert-Guroff, Michael G. Katze.
|
Steinbeck Forum |
| 6:30 P.M.
– 10:30 P.M. |
Strolling Dinner
|
Monterey Bay Aquarium |
| |
|
|
| Thursday,
September 13, 2007 |
| 7:00 A.M.
– 1:00 P.M. |
Registration Continues |
Monterey Conf. Ctr,
Steinbeck Lobby |
| 7:00 A.M.
– 8:00 A.M. |
Continental Breakfast |
Monterey Conf. Ctr,
Steinbeck Lobby |
| 8:00
A.M. – 10:50 A.M. |
Scientific Session
5: Therapeutics
Chair: Dr. Walid Heneine
Center for Disease Control
Co-Chair: Dr. Koen Van Rompay
California National Primate Research Center
|
Steinbeck Forum |
| 8:00 A.M. – 8:30 A.M. |
Presentation by Session Chair
Walid Heneine
Center for Disease Control
Prevention of rectal SHIV transmission by daily or
intermittent preexposure prophylaxis with tenofovir and emtricitabine
|
Steinbeck Forum |
| 8:30 A.M. – 8:50 A.M. |
Abstract 28 —
Extensive in vivo trafficking of adoptively transferred expanded CD4+ T cells in SIV infected rhesus macaques.
*Nattawat Onlamoon, Nicholas Plagman, Ann E. Mayne, Kovit Pattanapanyasat, Aftab A. Ansari, Francois Villinger.
|
Steinbeck Forum |
| 8:50 A.M. – 9:10 A.M. |
Abstract 29 —
Reduced Viremia and Delayed Disease Progression Following Immunotherapy of SIV with Peptide Pulsed Blood.
Stephen J. Kent, *Caroline Fernandez, Miranda Smith, Viv Peut, C. Jane Batten, Erik Rollman, Liyen Loh, Sheilajen Alcantara, Rosemarie Mason, Matthew Law, Amanda Handley, Robert De Rose.
|
Steinbeck Forum |
| 9:10 A.M. – 9:30 A.M. |
Abstract 30 —
Intermittent Antiretroviral Prophylaxis with Tenofovir and Emtricitabine Protects Macaques Against Repeated Rectal SHIV Exposures.
*J. Gerardo García-Lerma, Ron Otten, Mian-er Cong, Silvina Masciotra, Wei Luo, James Mitchell, Robert Janssen, Thomas Folks, Walid Heneine.
|
Steinbeck Forum |
| 9:30 A.M. – 9:50 A.M. |
Abstract 31 —
Allogeneic Lymphocyte Transfer in SIV+ Macaques.
*Justin Greene, Benjamin Burwitz, Alex Blasky, Roger Wiseman, Shelby O’Connor, David O’Connor.
|
Steinbeck Forum |
| 9:50 A.M. – 10:10 A.M. |
Abstract 32 —
Effect of Combined Antiretroviral Therapy on Brain Virus Lakshmanan Annamalai, Susan V. Westmoreland, Douglas R. Pauley, Heber G. Domingues, Dennis G. Walsh, Kenneth Williams, Eva Ratai, Margaret R. Lentz, Prabhat K. Sehgal, Raymond Schinazi, Norbert Bischofberger, R. Gilberto González, Shawn P. O’Neil.
|
Steinbeck Forum |
| 10:10 A.M. – 10:30 A.M. |
Abstract 33 —
Pharmacokinetics, toxicity and functional studies of the selective Kv1.3 channel blocker PAP-1 in the non-human primate rhesus macaque.
Lara E. Pereira, Francois Villinger, Heike Wulff, Ananthakrishnan Sankaranarayanan, Girija Raman, Aftab A. Ansari.
|
Steinbeck Forum |
| 10:30 A.M. – 10:50 A.M. |
Abstract 34 —
Chronic administration of tenofovir (PMPA) to rhesus macaques from infancy throughout adulthood and pregnancy: correlations between pharmacokinetics, toxicity, and virological effects.
Koen K. A. Van Rompay, Laurie L. Brignolo, Lucie Durand-Gasselin, Adrian S. Ray, Tomas Cihlar, Brian P. Kearney, Marta L. Marthas, Hans Reiser, Norbert Bischofberger.
|
Steinbeck Forum |
| 11:00 A.M.
– 11:30 A.M. |
Morning Break
|
|
| 11:30
A.M. – 12:30 P.M. |
Scientific Session
6: Invited Perspectives
Chair: Dr. Bonnie Matheson
Office of AIDS Research, NIH
|
Steinbeck Forum |
| 11:30 A.M. – 12:00 P.M. |
Nancy Haigwood, University of Washington
The perspective of the nonhuman primate model for AIDS
|
Steinbeck Forum |
| 12:00 P.M. – 12:30 P.M. |
Jeff Lifson, SAIC-Fredericks, Inc.
The strengths and limitations of current AIDS models.
|
Steinbeck Forum |
| 12:30 P.M.
– 12:45 P.M. |
Preview of the 26th
Annual Symposium of Nonhuman Primate Models for AIDS
|
Steinbeck Forum |
| 12:45P.M.
– 1:00 P.M. |
Closing Remarks
Dr. Christopher Miller
California National Primate Research Center
|
Steinbeck Forum |
|
|
