The CNPRC houses over 5,000 monkeys for research and breeding. Research at the Center spans the entire life history of these primates, ranging from gametes through fetal biology and neonatology, to the juvenile, adult and geriatric stages of life. We take the stewardship, welfare and care of the animals seriously, and the extensive teams of veterinarians, clinical and service laboratories, animal care, pathology, enrichment and behavior management staff work together to provide outstanding care to all of the animals.
The large field corrals house naturalistic demographics of infants to geriatric animals in their extended family groups. Healthy geriatric animals remain in these outdoor corrals with family members in the rich social environment of their home community. In addition to day-to-day health care for all animals, geriatric animals receive semi-annual geriatric veterinary workups and evaluations.
The CNPRC has a population of approximately 100 South American titi monkeys (Callicebus cupreus). These monkeys are small, tree-dwelling primates from South America, and live in monogamous family groups that consist of the parents and their offspring. The father is the main caretaker for the infants, bringing the infant to its mother only for nursing until the infant is weaned at around 5 months of age. Titi monkeys are used in noninvasive biobehavioral studies of attachment and parental behavior, as well as in studies of autism treatments and understanding normal brain and behavioral development. Titi monkeys allow us to understand social bonds, particularly in adult males, which form attachment bonds unlike most other mammalian species.
Understanding social bonds, particularly in adult titi males, also contributes to titi monkey health; for instance, CNPRC scientists have studied how their formation of social bonds can reduce stress and lower glucose levels in pair-bonded titi monkeys.
Specific Pathogen Free Primates
Since 1987, the CNPRC has been establishing specific pathogen free (SPF) monkey colonies with additional support by the National Institutes of Health. The goal of this breeding program is to improve both the overall nonhuman primate colony health and improve the quality of science conducted through eliminating persistent viral infections representing potential confounding variables. The CNPRC colony now consists of more than 1,700 SPF animals, which also increases personnel safety for animal care staff by reducing health risks associated with potential exposure to nonhuman primate pathogens.
National Institute on Aging, CNPRC Aged Monkey Colony
The National Institute on Aging (NIA), a division of the National Institutes of Health, supports research on aging rhesus monkeys at multiple National Primate Research Centers including the CNPRC. The CNPRC NIA Colony of geriatric rhesus macaques (≥19 years) has approximately 42 animals, and is managed and supported for use by investigators in aging research. The NIA Colony and all geriatric monkeys at the CNPRC participate in semi-annual assessments by the veterinary staff (e.g., physical examination, clinical pathology) to ensure overall health and to monitor for potential age-related complications. The Colony Management and Research Services staff also track eligible animals in the CNPRC breeding corrals for potential recruitment to the NIA Colony at 19 years of age.
This program aims to:
- Support and maintain NIA rhesus monkeys for investigators nationwide that are conducting aging-related research. The goal is to proactively manage the NIA Colony in order to maximize the number of healthy geriatric rhesus monkeys for aging research. The Primate Services staff work closely together with investigators to support translational rhesus monkey models of human aging.
- Provide expertise and services at the highest quality level for investigators at the local, regional, and national levels. Through established protocols, guidelines, and expertise ensure investigators are provided sufficient healthy, well-characterized aged animals and correlative services and infrastructure to support aging and lifespan health research objectives.