About the Infectious Diseases Unit
Research in the Infectious Diseases Unit
- Developing the SIV/rhesus macaque pediatric model of disease, to better understand the pathogenesis of SIV/HIV in neonates and test strategies for immunoprophylaxis and antiviral therapy to prevent infection or slow disease progression. Drug therapies used to prevent the transmission of HIV from mother to infant were developed in nonhuman primate models, and are now being successfully used in many human populations to protect millions of infants from contracting HIV.
- Using the nonhuman primate model of human cytomegalovirus (HCMV) to develop novel strategies to prevent HCMV in susceptible individuals, such as AIDS patients, transplant recipients, and some fetuses and newborns
- Defining our understanding of which viral genes are critical for the pathogenesis of AIDS
- Ongoing studies to further our understanding of the epidemiology and zoonotic potential of nonhuman primate infectious diseases, including developing better diagnostic tools for these studies
- Investigating the mechanisms of SIV/SHIV mucosal transmission, and the biology of the immune system in the female genital tract, information critical to develop effective HIV vaccines