About the Neuroscience and Behavior Unit
The Neuroscience and Behavior Unit provides services, training, consulting and collaborative expertise in the areas of basic neuroscience, stress physiology, psychoneuroimmunology, cognitive neuroscience, epigenomics, and psychosocial processes in nonhuman primates. NB Unit research focuses on integrating multiple levels of analysis (social, psychological, physiological, neurobiological, and genetic) across the lifespan to help alleviate the burdens on individuals and society of mental illness and neurodegenerative disease.
Research Accomplishments in the Neuroscience and Behavior Unit
- Showed that social stress accelerates progression of immunodeficiency virus disease and identified social and personality factors that are protective against disease progression.
- Demonstrated that an individual’s social role in its group is associated with markers of inflammation.
- Discovered that the activation of the maternal immune system during pregnancy can lead to brain, immune, and behavioral outcomes that are similar to those seen in autism spectrum disorder and schizophrenia.
- Showed that gene therapy could affect brain and behavioral functioning in a model of Alzheimer’s Disease. This work has led to clinical trials in humans.
- Identified changes in synaptic boutons in the prefrontal cortex that were associated with memory deficits in a model of menopause.
- Found striking parallels in physiological organization between lonely humans and a naturally-occurring model of loneliness in monkeys, leading to new studies of immune cell maturation in lonely monkeys.
- Identified the distribution of oxytocin and vasopressin receptors in the titi monkey brain. Titi monkeys are an important model for pair bonding in adulthood.
- Successfully showed that DREADDS (Designer Receptors Exclusively Activated by Designer Drugs) could be used in a nonhuman primate to temporarily inactivate brain structures.
- Showed that emotion regulation of juveniles receiving the widely used antidepressant fluoxetine (Prozac) was dependent on genotype for monoamine oxidase-A, a result that could explain the variation seen in children who are treated with selective serotonin reuptake inhibitors like fluoxetine.
- Demonstrated that the macaque autonomic nervous system codes for affective information in a manner identical to the human system.
- Showed that aspects of an individual’s social network, involving identification of “friends” and “friends of friends” reduces infectious disease in individuals, which is contrary to established infectious disease theory.
- Linked early maternal care with offspring adult health outcomes via early epigenetic re-programming
BioBehavioral Assessment Program
The BioBehavioral Assessment (BBA) Program is a resource that is unique in the National Primate Research Centers system. The Program comprises a highly standardized series of assessments designed to quantify variation in basic indicators of psychological and physiological organization (anxiety, affect regulation, social attention and responsiveness, hypothalamic-pituitary-adrenal regulation, genotypes for 5-HTTLPR and MAOA-LPR) in infant rhesus monkeys. Begun in 2001, more than 4000 animals have been assessed, many of which are still living in the colony. Quantitative data from the BBA Program are available to qualified investigators for mining and hypothesis testing, and for subject selection for their own projects. It is also possible for investigators to enroll their own animals in the Program for assessment. For more information, contact BBAProgram@ucdavis.edu.