Inhalation Exposure Core

///Inhalation Exposure Core
Inhalation Exposure Core 2017-04-13T18:36:39+00:00

The primary mission of the Inhalation Exposure Core  is to serve as a state-of-the-art facility and educational resource for the design, completion, analysis, and interpretation of studies involving health effects of airborne materials. The Inhalation Exposure Core provides short- and long-term generation, delivery, and analysis of precisely controlled atmospheres to investigate human health effects of environmental challenges using both in vitro and in vivo laboratory animal models. In coordination with Primate Medicine Services, the Inhalation Exposure Core also provides pulmonary function testing and bronchoscopy as outcome measures for health effects as a result of exposures in nonhuman primates. Relatively non-invasive methods, including pulmonary transfer impedance, are used for measuring airway reactivity and other physiological responses of the respiratory system. With an emphasis on inhalation toxicology and animal models of chronic respiratory disease, Inhalation Exposure Core faculty and staff provide critical intellectual expertise and technical support for investigators to conduct research projects that require evaluation of biological responses to atmospheric exposures.

Resources and Capabilities

  • Inhalation Toxicology Expertise
  • Large In Vivo and In Vitro Exposure Capacity
  • Aerosol Generation and Characterization
  • Major Gaseous Pollutant Generation and Monitoring
  • Pulmonary Function Testing and Bronchoscopy Suite
  • GLP Study Capabilities
  • Project, Data, and Sample Management

Examples of Animal Models Offered

  • Inhaled Therapeutic Trials
  • Adult Allergic Asthma
  • Adult Non-Allergic (Intrinsic) Asthma
  • Pediatric Allergic Asthma
  • Air Pollution (Ozone, PM, Tobacco Smoke) Inhalation
  • Endotoxin Inhalation
  • Adult and Pediatric Influenza
  • Coming Soon: Wood Smoke Inhalation

Our History

In the early 1970s, Drs. Donald L. Dungworth and Walter S. Tyler, who shared common research interests in the health effects of air pollutants, brought together a multidisciplinary group of scientists. They were successful in obtaining funding from NIEHS for the program project “Pulmonary Effects of Environmental Oxidant Pollutants” starting in 1971. The Inhalation Exposure Core was a key part of this project. In 1972 this facility relocated to the Primate Center where there was opportunity for expansion and the availability of nonhuman primates. Investigators in the Respiratory Diseases Unit obtained additional funding from the Environmental Protection Agency, Department of Energy and Electric Power Research Institute to permit further expansion of capabilities. In the early 1990’s, systems were developed to permit in vitro exposure of cultured cell and tissues to oxidant gases. Over the years, the expertise of this facility has grown to include abilities to conduct exposures to oxidant gases, reactive gases, aerosols, mixed gas and aerosols (including tobacco smoke), allergens, microbes, and various drug-containing entities, such as DNA preparations, antibodies, endotoxin or liposomes.

Beginning in 2000, under the leadership of Dr. Charles G. Plopper (UC Davis School of Veterinary Medicine, Emeritus), an important and major effort was initiated to study the development and exacerbation of asthma by oxidant air pollutants in nonhuman primates. The asthma studies necessitated the establishment of a pulmonary function laboratory with extensive capabilities for testing nonhuman primates under the direction of a pulmonary physiologist to assess function in animals undergoing exposure. Under the leadership of Dr. Dallas Hyde (UC Davis School of Veterinary Medicine, Emeritus), funding was obtained in 2010 from the US government – American Recovery and Regeneration Act – to build a Respiratory Disease Center including a new inhalation exposure facility. It was recognized that the CNPRC is the only primate center with an inhalation exposure facility and respiratory diseases unit, enhancing research with nonhuman primate models of respiratory diseases. 

Contact the IEC

To learn more about our capabilities and to inquire about conducting research with the IEC, please see the Services page.

Christopher M. Royer, D.V.M., Ph.D.
Respiratory Diseases Unit

Lisa A. Miller, Ph.D.
Respiratory Diseases Unit

Visit Dr. Miller’s page