Multimodal Imaging Core

Home/Our Services/Core Services/Multimodal Imaging Core
Multimodal Imaging Core 2016-10-14T18:02:54+00:00

In Vivo Imaging Core at CNPRC

The Multimodal Imaging Core provides services to investigators locally, regionally, and nationally, encompassing scales that range from cellular to whole-animal imaging. The goal of the Core is to support the research of investigators in qualitative and quantitative imaging applications and to assist with study design, data interpretation, grant submissions, and to conduct preclinical and IND-enabling studies.

In vivo imaging services provided by Core faculty and trained professionals includes ultrasound imaging, optical imaging, positron emission tomography/computed tomography (PET/CT), and microPET, in addition to radiochemistry and pharmacokinetic analyses of new radiopharmaceuticals.

Dedicated faculty and staff are responsible for imaging services, radiotracer synthesis, administrative support, day-to-day operational management, computer support, preventive and routine maintenance, and quality assurance.

The Core also provides histology (e.g., hematoxylin and eosin staining) and immunohistochemistry services specific to nonhuman primates, as well as expertise, training, and access to microscopy-based equipment that supports routine imaging modalities (e.g., digital image capture with brightfield, Nomarski/differential interference contrast, and fluorescence microscopy) as well as services related to whole slide scanning

Multimodal Imaging Core Capabilities and Resources

The Core develops innovative methods and techniques including:

  • Highly innovative methods for bioluminescence imaging in monkeys for a spectrum of gene therapy and stem cell transplantation studies
[Tarantal and Lee, 2010; Tarantal et al., 2012; Tarantal and Skarlatos 2012]. These include studies performed for investigators in the NHLBI Center for Fetal Monkey Gene Transfer for Heart, Lung, and Blood Diseases.
  • Improved contrast-to-noise imaging performance for cell trafficking studies has been accomplished with the development of new copper (64Cu) and zirconium (89Zr) radioimmunoconjugates for successfully radiolabeling and tracking stem and progenitor cells post-transplantation [Tarantal et al., 2012; 2013].
  • New PET radiotracers have been developed which are now available in the Core and include 11C-PK11195 and 18F-PBR111 that bind to the translocator protein (TSPO) for neuroinflammation, 18F-FMT for studying dopamine synthesis, and 11C-PIB for amyloid imaging.
  • Publications

    Abbas AR, Jackman JK, Bullens SL, Davis SM, Choy DF, Fedorowicz G, Tan M, Truong B-T, Gloria Meng Y, Diehl L, Miller LA, Schelegle ES, Hyde DM, Clark HF, Modrusan Z, Arron JR, and Wu LC. Lung gene expression in a rhesus allergic asthma model correlates with physiologic parameters of disease and exhibits common and distinct pathways with human asthma and a mouse asthma model. Am J Pathol 179: 1667-1680, 2011. PMCID: PMC3181391, PMID 21819959

    Abbott DH, Bruns CR, Barnett DK, Dunaif A, Goodfriend TL, Dumesic DA, and Tarantal AF. Experimentally-induced gestational androgen excess disrupts glucoregulation in rhesus monkey dams and their female offspring. Am J Physiol Endocrinol Metab 299: E741-751, 2010. PMCID: PMC2980359, PMID 20682841

    Albertine KH, Dahl MJ, Gonzales LW, Wang ZM, Metcalfe D, Hyde DM, Plopper CG, Starcher BC, Carlton DP, and Bland RD. Chronic lung disease in preterm lambs: effect of daily vitamin A treatment on alveolarization. Am J Physiol Lung Cell Mol Physiol 299:L59-L72, 2010. PMCID: PMC2904099, PMID 20382748

    Ardeshir A, Oslund KL, Ventimiglia F, Yee J, Lerche NW, and Hyde DM. Idiopathic microscopic colitis of rhesus macaques: Quantitative assessment of colonic mucosa. Anat Rec (Hoboken) 296: 1169-1179, 2013. PMC Journal-in-Progress PMID 23775860

    Avdalovic MV, Tyler NK, Putney L, Nishio SJ, Quesenberry S, Singh PJ, Miller LA, Schelegle ES, Plopper CG, Vu T, and Hyde DM. Ozone exposure during the early postnatal period alters the timing and pattern of alveolar growth and development in nonhuman primates. Anat Rec (Hoboken) 295: 1707-1716, 2012. PMC Journal-in-Progress PMID 22887719

    Bakkour S, Baker CA, Tarantal AF, Wen L, Busch MP, Lee TH, and McCune JM. Analysis of maternal microchimerism in rhesus monkeys (Macaca mulatta) using real-time quantitative PCR amplification of MHC polymorphisms. Chimerism 5:6-15, 2014. PMCID: PMC3988117, PMID 24451553

    Batchelder CA, Duru N, Lee CI, Baker CA, Swainson L, McCune JM, and Tarantal AF. Myeloid-lymphoid ontogeny in the rhesus monkey (Macaca mulatta). Anat Rec (Hoboken), 2014. PMC4120262

    Batchelder CA, Keyser JL, Lee CC, and Tarantal AF. Characterization of growth, glomerular number, and tubular proteins in the developing rhesus monkey kidney. Anat Rec (Hoboken) 296: 1747-1757, 2013. PMC Journal-in-Progress PMID 23997038

    Batchelder CA LC, Martinez ML, and Tarantal AF. Ontogeny of the kidney and renal developmental markers in the rhesus monkey (Macaca mulatta). Anat Rec 293: 1971-1983, 2010. PMCID: PMC3163141

    Bauman MD, Iosif AM, Ashwood P, Braunschweig D, Lee A, Schumann CM, Van de Water J, and Amaral DG. Maternal antibodies from mothers of children with autism alter brain growth and social behavior development in the rhesus monkey. Transl Psychiatry 3: e278, 2013. PMCID: PMC3731783, PMID 23838889

    Bauman MD, Iosif AM, Smith SE, Bregere C, Amaral DG, and Patterson PH. Activation of the maternal immune system during pregnancy alters behavioral development of rhesus monkey offspring. Biol Psychiatry 75: 332-41, 2013. PMC Journal-in-Progress PMID 24011823

    Bell P, Wang L, Gao G, Haskins ME, Tarantal AF, McCarter RJ, Zhu Y, Yu H, and Wilson JM. Inverse zonation of hepatocyte transduction with AAV vectors between mice and non-human primates. Mol Genet Metab 104: 395-403, 2011. PMCID: PMC3269907, PMID 21778099

    Binny C, McIntosh J, Della Peruta M, Kymalainen H, Tuddenham EGD, Buckley SMK, Waddington SN, McVey JH, Spence Y, Morton CL, Thrasher AJ, Gray JT, Castellino FJ, Tarantal AF, Davidoff AM, and Nathwani AC. AAV-mediated gene transfer in the perinatal period results in expression of FVII at levels that protect against fatal spontaneous hemorrhage. Blood 119: 957-966, 2012. PMCID: PMC3271720, PMID 22134170

    Capitanio JP, Miller LA, Schelegle ES, Mendoza SP, Mason WA, and Hyde DM. Behavioral inhibition is associated with airway hyperresponsiveness but not atopy in a monkey model of asthma. Psychosom Med 73: 288-294, 2011. PMCID: PMC3090450, PMID 21536834

    Carbonaro Sarracino D, Tarantal AF, Lee CC, Martinez M, Jin X, Wang X, Hardee CL, Geiger S, Kahl CA, and Kohn DB. Effects of vector backbone and pseudotype on lentiviral vector-mediated gene transfer: studies in infant ADA-deficient mice and rhesus monkeys. Mol Ther 22:1803-1816, 2014. PMCID: PMC4428412.

    Carey SA, Ballinger CA, Plopper CG, McDonald RJ, Bartolucci AA, Postlethwait EM, and Harkema JR. Persistent rhinitis and epithelial remodeling induced by cyclic ozone exposure in the nasal airways of infant monkeys. American J of Physiology Lung Cellular and Molecular Physiology 300: L242-254, 2011. PMC3043815, PMID 21131400

    Carey SA, Plopper CG, Hyde DM, Islam Z, Pestka JJ, and Harkema JR. Satratoxin-G from the black mold Stachybotrys chartarum induces rhinitis and apoptosis of olfactory sensory neurons in the nasal airways of rhesus monkeys. Toxicol Pathol 40: 887-98, 2012. PMC Journal-in-Progress PMID 22552393

    Chaffin CL, Latham KE, Mtango NR, Midic U, and VandeVoort CA. Dietary sugar in healthy female primates perturbs oocyte maturation and in vitro preimplantation embryo development. Endocrinology 155:2688-2695, 2015. PMCID: PMC4060180

    Chaffin CL, Lee YS, VandeVoort CA, Patel BG, and Latham KE. Rhesus monkey cumulus cells revert to a mural granulosa cell state after an ovulatory stimulus. Endocrinology 153: 5535-5545, 2012. PMCID: PMC3473200, PMID 23008515

    Chan JK, Fanucchi MV, Anderson DS, Abid AD, Wallis CD, Dickinson DA, Kumfer BM, Kennedy IM, Wexler AS, and Van Winkle LS. Susceptibility to inhaled flame-generated ultrafine soot in neonatal and adult rat lungs. Toxicol Sci 124:472, 2011. PMCID: PMC3216412, PMID 21914721

    Chou DL, Gerriets JE, Schelegle ES, Hyde DM, and Miller LA. Increased CCL24/eotaxin-2 with postnatal ozone exposure in allergen-sensitized infant monkeys is not associated with recruitment of eosinophils to airway mucosa. Toxicol Appl Pharmacol 15;257: 309-18, 2011. PMCID: PMC3226879, PMID 21945493

    Chun K, Miller LA, Schelegle ES, Hyde DM, and Capitanio JP. Behavioral inhibition in rhesus monkeys (Macaca mulatta) is related to the airways response, but not immune measures, commonly associated with asthma. PLoS One 8:e71575, 2013. PMCID: PMC3739724, PMID 23951195

    Davis BB, Zeki AA, Bratt JM, Wang L, Filosto S, Walby WF, Kenyon NJ, Goldkorn T, Schelegle ES, and Pinkerton KE. Simvastatin inhibits smoke-induced airway epithelial injury: implications for COPD therapy. Eur Respir J 42: 350-361, 2013. PMC Journal-in-Progress PMID 23180589

    Elsworth JD, Jentsch JD, VandeVoort CA, Roth RH, Jr DE, and Leranth C. Prenatal exposure to bisphenol A impacts midbrain dopamine neurons and hippocampal spine synapses in non-human primates. Neurotoxicology 35: 113-120, 2013. PMCID: PMC3660149, PMID 23337607

    Enkhmaa B, Abbuthalha A, Anuurad E, Zhang W, Tarantal AF, and Berglund L. Rhesus monkey (Macaca mulatta) lipoprotein(a) and apolipoprotein(a): high frequency of small size apolipoprotein(a) isoforms. J Med Primatol 44:117-124, 2015. PMCID: PMC4430394

    Evans MJ, Fanucchi MV, Plopper CG, and Hyde DM. Postnatal development of the lamina reticularis in primate airways. Anat Rec (Hoboken) 293: 947-954, 2010. PMC Journal-in-Progress PMID 20503389

    Freedenberg MI, Badawi RD, Tarantal AF, and Cherry SR. Performance and limitations of positron emission tomography (PET) scanners for imaging very low activity sources. 30: 104-10, 2013. PMCID: PMC3795820, PMID 23680361

    Freeman SM, Walum H, Inoue K, Smith AL, Goodman MM, Bales KL, and Young LJ. Neuroanatomical distribution of oxytocin and vasopressin 1a receptors in the socially monogamous coppery titi monkey (Callicebus cupreus). Neuroscience 273:12-23, 2014. PMCID: PMC4083847

    Gharib SA, Altemeier WA, Van Winkle LS, Plopper CG, Schlesinger SY, Buell CA, Brauer R, Lee V, Parks WC, and Chen P. Matrix metalloproteinase-7 coordinates airway epithelial injury response and differentiation of ciliated cells. Am J Respir Cell Mol Biol 48:390-396, 2013. PMCID: PMC3604090, PMID 23258229

    Golub MS. Recent studies of iron deficiency during brain development in nonhuman primates. Biofactors 36:111-116, 2010. PMC Journal-in-Progress, PMID 20336711

    Golub MS, Hogrefe CE, and Unger EL. Influence of prenatal iron deficiency and MAOA genotype on response to social challenge in rhesus monkey infants. Genes Brain Behav 11:278-290, 2012. PMCID: PMC3511847, PMID22340208

    Golub MS, Hogrefe CE, and Vandevoort CA. Binge drinking prior to pregnancy detection in a nonhuman primate: behavioral evaluation of offspring. Alcohol Clin Exp Res 38:551-556, 2014. PMCID: PMC4201374

    Hallstrand TS, Lai Y, Altemeier WA, Appel CL, Johnson B, Frevert CW, Hudkins KL, Bollinger JG, Woodruff PG, Hyde DM, Henderson WR, and Gelb MH. Regulation and function of epithelial secreted phospholipase A2 group X in asthma. Am J Respir Crit Care Med 188: 42-50, 2013. PMCID: PMC3735246, PMID 23614662

    Herring MJ, Avdalovic MV, Quesenberry CL, Putney LF, Tyler NK, Ventimiglia FF, St. George JA, and Hyde DM. Accelerated structural decrements in the aging female rhesus macaque lung compared to males. Am J Physiol Lung Cell Mol Physiol 304: L125-134, 2013. PMCID: PMC3543639, PMID 23144321

    Herring MJ, Putney LF, St George JA, Avdalovic MV, Schelegle ES, Miller LA, and Hyde DM. Early life exposure to allergen and ozone results in altered development in adolescent rhesus macaque lungs. Toxicol Appl Pharmacol 283:35-41, 2015. PMID: 25545987

    Herring MJ, Putney LF, Wyatt G, Finkbeiner WE, and Hyde DM. Growth of alveoli during postnatal development in humans based on stereological estimation. Am J Physiol Lung Cell Mol Physiol 307:L338-44, 2014. PMCID: PMC4137164 PMID: 24907055

    Hinderer C, Bell P, Louboutin JP, Zhu Y, Yu H, Lin G, Choa R, Gurda BL, Bagel J, O’Donnell P, Sikora T, Ruane T, Wang P, Tarantal AF, Casal ML, Haskins ME, and Wilson JM. Neonatal systemic AAV induces tolerance to CNS gene therapy in MPS I dogs and nonhuman primates. Mol Ther 2015 doi: 10.1038/mt.2015.99. [Epub ahead of print] PMID: 26022732 Journal-in-Progress

    Hsia CC, Hyde DM, Ochs M, and Weibel ER. An official research policy statement of the American Thoracic Society/European Respiratory Society: standards for quantitative assessment of lung structure. Am J Respir Crit Care Med 181: 394-418, 2010. PMC Journal-in-Progress PMID 20130146

    Hunt PA, Lawson C, Gieske M, Murdoch B, Smith H, Marre A, Hassold T, and VandeVoort CA. Bisphenol A alters early oogenesis and follicle formation in the fetal ovary of the rhesus monkey. Proc Natl Acad Sci USA 109: 17525-17530, 2012. PMCID: PMC3491481, PMID 23012422

    Hyde DM and Simon SI. Polymorphonuclear leukocytes. In: Respiratory Toxicology, edited by Yost GS. New York: Elsevier, 2010.

    Kallapur SG, Presicce P, Senthamaraikannan P, Alvarez M, Tarantal AF, Miller LM, Jobe AH, and Chougnet CA. Intra-amniotic IL-1beta induces fetal inflammation in rhesus monkeys and alters the regulatory T cell/IL-17 balance. J Immunol 191: 1102-1109, 2013. PMCID: PMC3720768, PMID 23794628

    Kamath AV, Williams SP, Bullens S, Cowan KJ, Stenberg Y, Cherry SR, Rendig S, Kukis DL, Griesemer C, Damico-Beyer LA, and Bunting S. Pharmacokinetics and biodistribution of a human monoclonal antibody to oxidized LDL in cynomolgus monkey using PET imaging. PLoS One 7: e45116, 2012. PMCID: PMC3444451, PMID 23028793

    Lai Y, Altemeier WA, Vandree J, Piliponsky AM, Johnson B, Appel CL, Frevert CW, Hyde DM, Ziegler SF, Smith DE, Henderson WR, Jr., Gelb MH, and Hallstrand TS. Increased density of intraepithelial mast cells in patients with exercise-induced bronchoconstriction regulated through epithelially derived thymic stromal lymphopoietin and IL-33. J Allergy Clin Immunol 133: 1448-55, 2013. PMCID: PMC4004718, PMID 24220317

    Lara AR, Cosgrove GP, Janssen WJ, Huie TJ, Burnham EL, Heinz DE, Curran-Everett D, Sahin H, Schwarz MI, Cool CD, Groshong SD, Geraci MW, Tuder RM, Hyde DM, and Henson PM. Increased lymphatic vessel length is associated with the fibroblast reticulum and disease severity in usual interstitial pneumonia and non specific interstitial pneumonia. Chest 142: 1569-76, 2012. PMCID: PMC3515029, PMID 22797508

    Lee D, Wallis C, Van Winkle LS, and Wexler AS. Disruption of tracheobronchial airway growth following postnatal exposure to ozone and ultrafine particles. Inhal Toxicol 23:520-531, 2011. PMC Journal-in-Progress, PMID 21780864

    Lee D, Wallis C, Wexler AS, Schelegle ES, Van Winkle LS, Plopper CG, Fanucchi MV, Kumfer B, Kennedy IM, and Chan JK. Small particles disrupt postnatal airway development. J Appl Physiol 109:1115, 2010. PMC Journal-in-Progress, PMID 20634362

    Luciw PA, Oslund KL, Yang X-w, Adamson L, Ravindran R, Canfield DR, Tarara R, Hirst L, Christensen M, Lerche NW, Offenstein H, Lewinsohn D, Ventimiglia F, Brignolo L, Wisner ER, and Hyde DM. Stereologic analysis of bacterial load and lung lesions in nonhuman primates (rhesus macaques) experimentally infected with Mycobacterium tuberculosis. Am J Physiol Lung Cell Mol Physiol 301: 731-738, 2011. PMCID: PMC3213984, PMID 21873450

    Maniar-Hew K, Clay CC, Postlethwait EM, Evans MJ, Fontaine JH, and Miller LA. The innate immune response to LPS in airway epithelium is dependent upon chronological age and antecedent exposures. Am J Respir Cell Mol Biol 49:710-720, 2013. PMCID: PMC3931090, PMID 23600597

    Maniar-Hew K, Postlethwait EM, Fanucchi MV, Ballinger CA, Evans MJ, Harkema JR, Carey SA, McDonald RJ, Bartolucci AA, and Miller LA. Postnatal episodic ozone results in persistent attenuation of pulmonary and peripheral blood responses to LPS challenge. Am J Physiol Lung Cell Mol Physiol 300: L462-471, 2011. PMCID: PMC3064293, PMID 21131396

    Moore BD, Hyde DM, Miller LA, Wong EM, and Schelegle ES. Persistence of serotonergic enhancement of airway response in a model of childhood asthma. Am J Respir Cell Mol Biol 51:77-85, 2014. PMCID: PMC4091858

    Murphy SR, Schelegle ES, Edwards PC, Miller LA, Hyde DM, and Van Winkle LS. Postnatal exposure history and airways: oxidant stress responses in airway explants. Am J Respir Cell Mol Biol 47: 815-823, 2012. PMCID: PMC3547096, PMID 22962062

    Murphy SR, Oslund KL, Hyde DM, Miller LA, Van Winkle LS, and Schelegle ES. Ozone-induced airway epithelial cell death, the neurokinin-1 receptor pathway, and the postnatal developing lung. Am J Physiol Lung Cell Mol Physiol 307:L471-L481, 2014. PMCID: PMC4166783

    Murphy SR, Schelegle ES, Miller LA, Hyde DM, and Van Winkle LS. Ozone exposure alters serotonin and serotonin receptor expression in the developing lung. Toxicol Sci 134: 168-179, 2013. PMCID: PMC3693130, PMID 23570994

    Nakayama KH, Batchelder CA, Lee CI, and Tarantal AF. Decellularized rhesus monkey kidney as a three-dimensional scaffold for renal tissue engineering. Tissue Eng Part A 16:2207-2216, 2010. PMCID: PMC2947947, PMID 20156112

    Nakayama KH, Batchelder CA, Lee CI, and Tarantal AF. Renal tissue engineering with decellularized rhesus monkey kidneys: age-related differences. Tissue Eng Part A 17: 2891-2901, 2011. PMCID: PMC3226054, PMID 21902603

    Nakayama KH, Lee CC, Batchelder CA, and Tarantal AF. Tissue specificity of decellularized rhesus monkey kidney and lung scaffolds. PLoS One 8: e64134, 2013. PMCID: PMC3661477, PMID 23717553

    Nicol LE, O’Brien TD, Dumesic DA, Grogan T, Tarantal AF, and Abbott DH. Abnormal infant islet morphology precedes insulin resistance in PCOS-like monkeys. PLoS One 9:e106527, 2014. PMCID: PMC4160158

    Plopper CG, Joad JP, Miller LA, Schelegle ES, Fanucchi MV, Van Winkle LS, Tyler NK, Avdalovic MV, Evans MJ, Lasley WL, Buckpitt AR, Pinkerton KE, Tarkington BK, Davis S, Nishio SJ, Gershwin LJ, Wu R, and Hyde DM. Lung effects of inhaled corticosteroids in a rhesus monkey model of childhood asthma. Clin Exp Allergy 42: 1104-1118, 2012. PMCID: PMC3913647, PMID 22702509

    Schuler R, Smith DE, Kumaraguruparan G, Chervenak A, Lewis AD, Hyde DM, and Kesselman C. A flexible, open, decentralized system for digital pathology networks. Stud Health Technol Inform 175: 29-38, 2012. PMCID: PMC3966426, PMID 22941985

    Sekizawa S-i, Bechtold AG, Tham RC, Kott KS, Hyde DM, Joad JP, and Bonham AC. House-dust mite allergen and ozone exposure decreases histamine H3 receptors in the brainstem respiratory nuclei. Toxicol Appl Pharmacol 247: 204-210, 2010. PMC Journal-in-Progress PMID 20600210

    Sun YH, Reid B, Fontaine JH, Miller LA, Hyde DM, Mogilner A, and Zhao M. Airway epithelial wounds in rhesus monkey generate ionic currents that guide cell migration to promote healing. J Appl Physiol 111: 1031-41, 2011. PMCID: PMC3774198, PMID 21719726

    Tam S, Maksaereekul S, Hyde DM, Godinez I, and Beaman BL. IL-17 and gammadelta T-lymphocytes play a critical role in innate immunity against Nocardia asteroides GUH-2. Microbes infect. 14: 1133-1143, 2012. PMCID: PMC3483469, PMID 22634423

    Tarantal AF and Berglund L. Obesity and lifespan health–importance of the fetal environment. Nutrients 6:1725-1736, 2014. PMCID: PMC4011063

    Tarantal AF, Chen H, Shi T, Lu T, Fang A, Xu B, Kolb M, Gauldie J, Warburton D, and Shi W. Overexpression of TGF-ß1 in fetal rhesus monkey lung results in prenatal pulmonary fibrosis. Eur Resp J 36:907-914, 2010. PMCID: PMC3074616, PMID 20351039

    Tarantal AF, Lee C. Long-term luciferase expression monitored by bioluminescence imaging after adeno-associated virus-mediated fetal gene delivery in rhesus monkeys (Macaca mulatta). Hum Gene Ther 21: 143-148, 2010. PMCID: PMC2829449, PMID 19751148

    Tarantal AF, Lee CC, Batchelder CA, Christensen JE, Prater D, and Cherry SR. Radiolabeling and in vivo imaging of transplanted renal lineages differentiated from human embryonic stem cells in fetal rhesus monkeys. Mol Imaging Biol 14: 197-204, 2012. PMID 21479709

    Tarantal AF, Lee CC, Kukis DL, and Cherry SR. Radiolabeling human peripheral blood stem cells for positron emission tomography (PET) imaging in young rhesus monkeys. PLoS One 8: e77148, 2013. PMCID: PMC3789702, PMID 24098579

    Tarantal AF and Skarlatos SI. Center for fetal monkey gene transfer for heart, lung, and blood diseases: an NHLBI Resource for the gene therapy community. Hum Gene Ther 23: 1130-1135, 2012. PMCID: PMC3498881, PMID 22974119

    Tharp AP, Maffini MV, Hunt PA, VandeVoort CA, Sonnenschein C, and Soto AM. Bisphenol A alters the development of the rhesus monkey mammary gland. Proc Natl Acad Sci U S A 109: 8190-8195, 2012. PMCID: PMC3361442, PMID 22566636

    Van Winkle LS, Baker GL, Chan JK, Schelegle ES, and Plopper CG. Airway mast cells in a rhesus model of childhood allergic airways disease. Toxicol Sci 116: 313-322, 2010. PMCID: PMC2886865, PMID 20403968

    Van Winkle LS, Chan JK, Anderson DS, Kumfer BM, Kennedy IM, Wexler AS, Wallis C, Abid AD, Sutherland KM, and Fanucchi MV. Age specific responses to acute inhalation of diffusion flame soot particles: cellular injury and the airway antioxidant response. Inhal Toxicol 22:70-83, 2010. PMCID: PMC3111018, PMID 20961279

    VandeVoort CA, Grimsrud KN, Midic U, Mtango N, and Latham KE. Transgenerational effects of binge drinking in a primate model: implications for human health. Fertil Steril 103:560-569, 2015. PMCID: PMC4314404

    VandeVoort CA, Mtango NR, Midic U, and Latham KE. Disruptions in follicle cell functions in the ovaries of rhesus monkeys during summer. Physiol Genomics 47:102-112, 2015. PMCID: PMC4385968

    vom Saal FS, VandeVoort CA, Taylor JA, Welshons WV, Toutain PL, and Hunt PA. Bisphenol A (BPA) pharmacokinetics with daily oral bolus or continuous exposure via silastic capsules in pregnant rhesus monkeys: relevance for human exposures. Reprod Toxicol 45:105-116, 2014. PMCID: PMC4035044, PMID 24582107

    Wang L, Bell P, Lin J, Calcedo R, Tarantal AF, and Wilson JM. AAV8-mediated hepatic gene transfer in infant rhesus monkeys (Macaca mulatta). Mol Ther 19: 2012-2020, 2011. PMCID: PMC3222523, PMID 21811248

    Wongtrakool C, Wang N, Hyde DM, Roman J, and Spindel ER. Prenatal nicotine exposure alters lung function and airway geometry through α7 nicotinic receptors. Am J Respir Cell Mol Biol 46: 695-702, 2012. PMCID: PMC3359906, PMID 22246862

    Yunt ZX, Mohning MP, Barthel L, Kearns MT, Tuder RM, Hyde DM, Henson PM, and Janssen WJ. Kinetics of the angiogenic response in lung endothelium following acute inflammatory injury with bleomycin. Exp Lung Res 40:415-425, 2014. PMCID: PMC4165791