- Brain,
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NPRC Publication: "Linking Research to Healthy Living"
Related Resources
Center of Excellence in Translation Human Stem Cell Research
Respiratory Diseases Unit
Studies Related to the Effects of Air Pollutants on Childhood Asthma and Pulmonary Health
PRENATAL / NEONATAL
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Effects of tobacco smoke on pre- and postnatal lung development (ETS01):
This study was designed to test the impact of maternal cigarette smoking on the lung development of fetuses, infants and young children.
POSTNATAL
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Males exposed to ozone and allergen to 6 months of age (IAM01, IAM02, IAM05):
These studies were designed to test the impact of oxidant air pollutants on the development of allergic airways disease in young children, and also to test whether allergen sensitization at a very young age alters lung development.
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Males exposed to ozone to 6 months of age (ELI01):
This study was designed to identify the mechanisms by which very young children are rendered more susceptible to acute lung injury by oxidant air pollutants.
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Males exposed to ozone and allergen to 6 months of age, followed by 6 months of filtered air (IAM04):
This study was designed to test whether allergic airways disease and chronic oxidant lung injury produced in very young children by exposure to air pollutants is reversible if the exposure is alleviated.
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Males exposed to ozone and allergen to 3 months of age (IAM06):
This study was designed to identify the initiating events of allergic airways disease produced in very young children by exposure to oxidant air pollutants and allergens.
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Allergen Challenge - Pilot Study (IAM03):
This study was designed to identify the mechanisms by which allergen exposure promotes the postnatal development of mucosal immunity in the lungs of infants.
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Corticosteroid therapy in asthmatic infants - Pilot Study (FAN01):
This study was designed to identify the negative effects of steroid treatment in neonates on early postnatal growth of the respiratory system. Steroids were administered by intramuscular injection.
- Corticosteroid therapy in asthmatic infants (IAM07):
This study was designed to identify the therapeutic value of an inhalable steroid (Pulmicort) on prevention of environmentally induced allergic asthma in infants. Steroid were administered by inhalation.
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Lung development in normal infant Rhesus monkeys (Devlp):
This study is comprised of a series of databases summarizing postnatal growth and development of the respiratory system of the rhesus monkey.
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Airway growth patterns in normal rhesus monkeys (Cast):
This is a series of on going studies to define the postnatal growth pattern of tracheobronchial airways in the rhesus monkey based on the architecture of casts made of the conducting airways.
| Lung Cast of Macaque monkey lung showing numbered airway branching pattern . |
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