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Abstracts & Publications
Males exposed to ozone and allergen to 6 months of age.
Abstracts:
2000 Evans, M.J., L.S. Van Winkle, M.V. Fanucchi, V. Wong, D. Hyde and C.G. Plopper. Lateral intercellular space of tracheal epithelium of house dust mite sensitized rhesus monkeys. American Journal of Respiratory and Critical Care Medicine 161(3):A778.
2000 Fanucchi, M.V., N. Sasson, D. King, M.J. Evans, L.S. Van Winkle, V. Wong, Y.H. Zhao, R. Wu and C.G. Plopper. Airway mucous cell alterations in house dust mite sensitized rhesus monkeys. American Journal of Respiratory and Critical Care Medicine 161(3):A275.
2000 Fanucchi, M.V., V. Wong, D. Hinds, B. Tarkington, L.S. Van Winkle, M.J. Evans and C.G. Plopper. Repeated episodes of exposure to ozone alters postnatal development of distal conducting airways in infant rhesus monkeys. American Journal of Respiratory and Critical Care Medicine 161(3):A615.
2000 Plopper, C., L. Van Winkle, M. Fanucchi, M. Evans, A. Buckpitt and R. Wu. Alterations in the epithelial/mesenchymal throphic unit of conducting airways in rhesus monkeys exposed to house dust mite allergen. The Federation of American Societies for Experimental Biology Journal 14(4):A302.
2000 Smiley-Jewell, S., Z. Johnson, A. Weir, N. Yin, L. Van Winkle and C. Plopper. Three-dimensional mapping of smooth muscle in the distal conducting airways of the monkey, mouse, and rabbit. American Journal of Respiratory and Critical Care Medicine 161(3):A110.
2000 Walby, W.F., E.S. Schelegle, L.J. Gershwin, B.K. Tarkington, D.M. Hyde aC.G. Plopper. Effect of house dust mite allergen and ozone, alone or in combination in infant rhesus monkeys. American Journal of Respiratory and Critical Care Medicine 161(3):A274.
2001 Evans, M.J., M.V. Fanucchi, L.S. Van Winkle, L.A. Miller, D.A. King, C. Fleschner, L.J. Gershwin and C.G. Plopper. Postnatal remodeling of the basement membrane zone in the epithelial-mesenchymal trophic unit of infant rhesus monkeys sensitized with house dust mite allergen and exposed to ozone. American Journal of Respiratory and Critical Care Medicine 163(5):A91
2001 Boland, B., D. Morin, A.R. Buckpitt, E.S. Schelegle, L.J. Gershwin, M.V. Fanucchi, C.G. Plopper. Metabolism of naphthalene (NA) and 1-nitronapthalene (NN) to electrophilic species in dissected airways of neonatal rhesus macaques exposed to house dust mite antigen (HDMA) and episodic ozone. Toxicological Sciences 60(1):A570.
2001 Fanucchi, M.V., L. Tan, C.C. Clay, L.J. Gershwin, L.S. Van Winkle, M.J. Evans and C.G. Plopper. Postnatal remodeling of the mucous cell population of the epithelial-mesenchymal trophic unit in airways of infant rhesus monkeys exposed to ozone and allergen. American Journal of Respiratory and Critical Care Medicine 163(5):A93.
2001 Joad, J.P., K.S. Kott, J.M. Bric, X. Zheng, E.S. Schelegle, A.C. Bonham, C-Y. Chen, L.J. Gershwin, C.G. Plopper and K.E. Pinkerton. Videomicrometry of responsiveness of respiratory bronchioles from infant monkeys exposed to ozone and allergen. American Journal of Respiratory and Critical Care Medicine 163(5):925.
2001 Kott, K.S., K.E. Pinkerton, J.M. Bric, K. Avadhanam, C.G. Plopper and J.P. Joad. Videomicrometry of responsiveness of central and peripheral airways in rats and monkeys. American Journal of Respiratory and Critical Care Medicine 163(5):925.
2001 Larson, S.D., E.S. Schelegle, J. P. Joad, L.J. Gershwin, D.M. Hyde and C.G. Plopper. Postnatal remodeling of the neural components of the epithelial-mesenchymal trophic unit in the proximal airways of infant rhesus monkeys exposed to ozone and allergen. American Journal of Respiratory and Critical Care Medicine 163(5):A627.
2001 Miller, L.A., C.G. Plopper, D.M. Hyde, J.E. Gerriets, M.V. Fanucchi, B.K. Tarkington, V.J. Wong, L.J. Gershwin and L.S. Van Winkle. Neonatal pulmonary immune responses following episodic exposure to aerosolized house dust mite. American Journal of Respiratory and Critical Care Medicine 163(5):A601.
2001 Plopper, C.G., M.V. Fanucchi, E.S. Schelegle, L.A. Miller, L.J. Gershwin, L.S. Van Winkle, M.J. Evans, J. Joad, K.E. Pinkerton, A.R. Buckpitt, R. Wu and D.M. Hyde. Effect of ozone exposure on allergic responses to dust mite in rhesus monkeys. The Toxicologist 60(1):327.
2001 Plopper, C., M. Fanucchi, M. Evans, S. Larson, E. Schelegle, J. Joad, K. Pinkerton, L. Van Winkle, L. Gershwin, L. Miller, A. Buckpitt, D. Hyde. Remodeling of the epithelial-mesenchymal trophic unit by cyclis exposures to ozone and house dust mite allergen during postnatal development of tracheobronchial airways in infant rhesus monkeys. The FASEB Journal 15:A55.
2001 Schelegle, E. S., W.F. Walby, J. Bratt, J.P. Joad, L.J. Gershwin, B.K. Tarkington and C.G. Plopper. Afferent nerve activity in isolated trachea of infant rhesus monkeys episodically exposed to ozone and allergen. American Journal of Respiratory and Critical Care Medicine 163:A926.
2002 Baker, G.L., M.J. Evans, M.V. Fanucchi, L.S. Van Winkle, L.A. Miller, D.M. Hyde, L.J. Gershwin, E.S. Schelegle, C.Z. Wong, C.G. Plopper. Tracheobronchial airway mast cell distribution and phenotypes in infants using a non-human primate model of allergic asthma. American Journal of Respiratory and Critical Care Medicine 165:A812.
2002 Chen, C-Y., J.P. Joad, E.S. Schelegle, L.J. Gershwin, C.G. Plopper, A.C. Bonham. Episodic ozone exposure either alone or in combination with allergen in induces neuroplasticity in nucleus tractus solitarius (NTS) where lung sensory fibers first synapse. Keystone Symposia 2002 Abstract Book: Rethinking the Pathogenesis of Asthma, p. 57 (A205).
2002 Evans, M.J., M.V. Fanucchi, L.S. Van Winkle, G.L. Baker, A.D. Murphy, S. Nishio, E.S. Schelegle, L.J. Gershwin, D.M. Hyde, C.G. Plopper. Perlecan and fibroblast growth factor immunoreactivity during postnatal development and remodeling of the basement membrane zone of rhesus monkeys exposed to allergen and ozone. Keystone Symposia 2002 Abstract Book: Rethinking the Pathogenesis of Asthma, p. 57 (A208).
2002 Fanucchi, M.V., C.C. Clay, M.J. Evans, G.L. Baker, A.M. Chang, L.J. Gershwin, E.S. Schelegle, C.G. Plopper, A.R. Buckpitt. Alterations in intracellular and extracellular glutathione and mucins in infant rhesus monkeys following inhalation of allergen and ozone. Keystone Symposia 2002 Abstract Book: Rethinking the Pathogenesis of Asthma, p. 58 (A209).
2002 Fanucchi, M.V., C.C. Clay, M.J. Evans, G.L. Baker, A.M. Chang, L.J. Gershwin, E.S. Schelegle, C.G. Plopper, A.R. Buckpitt. Inhalation of allergen and ozone alters intra-and extracellular pulmonary glutathione and mucin in infant rhesus monkeys. American Journal of Respiratory and Critical Care Medicine 165:A54
2002 Gershwin, L.J., V.M. Mitchell, D.M. Hyde, L.A. Miller, E. S. Schelegle, C.G. Plopper. Isotype and allergen specificity of antibodies in response to chronic house dust mite allergen aerosol and ozone exposure in a primate model of asthma. American Journal of Respiratory and Critical Care Medicine 165:A481.
2002 Hyde, D.M., N.K. Tyler, R.T. DeHoff, L.F. Putney, L.A. Miller, J.E. Gerriets, J.L. Usachenko, M.Y. Stovall, M.J. Evans, M.V. Fanucchi, E.S. Schelegle, L.J. Gershwin, C.G. Plopper. Increased alveolar septation and loss of conducting airways in infant rhesus monkeys following inhalation of allergens and air pollutants. Keystone Symposia 2002 Abstract Book: Rethinking the Pathogenesis of Asthma, P. 58 (A210).
2002 Evans, M.J., L.S. Van Winkle, M.V. Fanucchi, G.L. Baker, A.E. Murphy, S. Nishio, E.S. Schelegle, L.J. Gershwin, D.M. Hyde, C.G. Plopper. Fibroblast growth factor and perlecan in the tracheal basement membrane zone of infant rhesus monkeys sensitized with house dust mite allergen. American Journal of Respiratory and Critical Care Medicine 165:A810.
2002 Hyde, D.M., N.K. Tyler, R.T. DeHoff, L.F. Putney, L.A. Miller, J.E. Gerriets, J.L. Usachenko, M.Y. Stovall, M.J. Evans, M.V. Fanucchi, E.S. Schelegle, L.J. Gershwin, C.G. Plopper. Increased alveolar septation and loss of conducting airways in infant rhesus monkeys following inhalation of allergens and air pollutants. American Journal of Respiratory and Critical Care Medicine 165:A811.
2002 Larsen, E.A., M.J. Evans, M.V. Fanucchi, L.S. Van Winkle, G.L. Baker, S. Nishio, E.S. Schelegle, L.J. Gershwin, C.G. Plopper. Remodeling of proximal and distal airways of infant rhesus monkeys sensitized with house dust mite antigen. American Journal of Respiratory and Critical Care Medicine 165:A811.
2002 Miller, L.A., J.E. Gerriets, L.F. Putney, M.Y. Stovall, N.K. Tyler, J.L. Usachenko, L.J. Gershwin, E. S. Schelegle, C.G. Plopper, D.M. Hyde. Pulmonary immune responses to house dust mite and air pollutants: A comparative analysis of infant and adult rhesus monkey. American Journal of Respiratory and Critical Care Medicine 165:A318.
2002 Plopper, C.G., M.V. Fanucchi, M.J. Evans, S.P. Larson, E.S. Schelegle, J.P. Joad, K.E. Pinkerton, L.S. Van Winkle, L.J. Gershwin, L.A. Miller, R. Wu, A.R. Buckpitt, D.M. Hyde. Allergen-ozone interactions in non-human primates. Keystone Symposia 2002 Abstract Book: Rethinking the Pathogenesis of Asthma, p. 38.
2002 Plopper, C.G., M.V. Fanucchi, M.J. Evans, S.P. Larson, E.S. Schelegle, J.P. Joad, K.E. Pinkerton, L.S. Van Winkle, L.J. Gershwin, L.A. Miller, R. Wu, A.R. Buckpitt and D.M. Hyde. Air pollution and allergen: negative impact on postnatal growth and development of the lungs. Fourth Annual UC Davis Conference for Environmental Health Scientists, August, Napa, California.
2002 Plopper, C., A. Weir, A. Murphy, V. Wong, M. Fanucchi, M. Evans, L. Van Winkle, S. Nishio, E. Schelegle, L. Miller, L. Gershwin, D. Hyde. Cyclic exposure to ozone disrupts postnatal growth of distal conducting airwys in infant rhesus monkeys. American Journal of Respiratory and Critical Care Medicine 165:A507.
2003 Baker, G., M. Evans, M.V. Fanucchi, D. Hyde and C.G. Plopper. Quantitation of airway mast cells: distribution and phenotypes in infant non-human primates with allergic airways disease. Federation of American Societies for Experimental Biology Journal 17(5):875.4.
2003 Evans, M.J., M.V. Fanucchi, L.S. Van Winkle, G.L. Baker, A.D. Murphy, S.J. Nishio, E.S. Schelegle, L.J. Gershwin, L.A. Miller, D.M. Hyde and C.G. Plopper. Depletion of perlecan and fibroblast growth factor-2 during development of the tracheal basement membrane zone in rhesus monkeys exposed to ozone and allergen. American Journal of Respiratory and Critical Care Medicine 167(7):A342.
2003 Fanucchi, M.V., M.J. Evans, G.L. Baker, D.M. Hyde and C.G. Plopper. Quantitation of airway mucous goblet cells: effect of coexposure to ozone and allergen on site-specific distribution in infant and adult non-human primates. Federation of American Societies for Experimental Biology Journal 7(5):875.5
2003 Hyde, D.M., N.K. Tyler, L.F. Putney, E.K. McKenna, L.A. Miller and C.G. Plopper. Loss of alveolar septation during postnatal development in infant rhesus monkeys following inhalation of allergen and ozone. American Journal of Respiratory and Critical Care Medicine 167(7):A341.
2003 Joad, J.P., K.S. Kott, J.M. Bric, X. Zheng, J.L. Peake, L.J. Gershwin, C.G. Plopper, E.S. Schelegle and K.E. Pinkerton. Histology and responsiveness of bronchial slices from infant monkeys episodically exposed to ozone and/or allergen. American Journal of Respiratory and Critical Care Medicine 167(7):A494.
2003 Miller, L.A., N.K. Tyler, L.J. Gershwin, E.S. Schelegle, C.G. Plopper and D.M. Hyde. Localization of immune cells within airways following exposure to allergens and air pollutants: a comparative analysis of infant and adult rhesus monkeys. Federation of American Societies for Experimental Biology Journal 17(5):875.3
2003 Van Winkle, L.S., E. Kalashnikova, L.A. Miller, J.A. Shimizu, C.D. Brown, E.S. Schelegle, L.J. Gershwin, P.L. Sannes, D.M. Hyde, M.J. Evans and C.G. Plopper. FGF-2 Distribution and abundance in tracheal explants from infant and adult rhesus monkeys exposed to HDMA. American Journal of Respiratory and Critical Care Medicine 167(7):A463.
Publications:
2001 Chen, C-Y., A.C. Bonham, E.S. Schelegle, L.J. Gershwin, C.G. Plopper and J.J. Joad. Extended allergen exposure in asthmatic monkeys induces neuroplasticity in nucleus tractus solitarius. Journal of Allergy and Clinical Immunology 108:557-562.
2002 Evans, M.J., L.S. Van Winkle, M.V. Fanucchi, G.L. Baker, A.E. Murphy, S.J. Nishio, E.S. Schelegle, L.J. Gershwin, P.L. Sannes and C.G. Plopper. Fibroblast growth factor-2 in remodeling of the developing basement membrane zone in the trachea of infant rhesus monkeys sensitized and challenged with allergen. Laboratory Investigation 82:1747-1754.
2002 Evans, M.J., M.V. Fanucchi, L.S. Van Winkle, G.L. Baker, A.E. Murphy, S.J. Nishio, P.L. Sannes and C.G. Plopper. Fibroblast growth factor-2 during postnatal development of the tracheal basement membrane zone. American Journal of Physiology: Lung, Cellular and Molecular Physiology 283:L1263-L1270.
2002 Smiley-Jewell, S.M., M.U. Tran, A.J. Weir, Z.A. Johnson, L.S. Van Winkle and C.G. Plopper. Three-dimensional mapping of smooth muscle in the distal conducting airways of mouse, rabbit, and monkey. Journal of Applied Physiology 93:1506-1514.
2002 Kott, K.S., K.E. Pinkerton, J.M. Bric, C.G. Plopper, K.P. Avadhanam and J.P. Joad. Methacholine responsiveness of proximal and distal airways of monkeys and rats using videomicrometry. Journal of Applied Physiology 92(3):989-996.
2003 Chen, C.Y., A.C. Bonham, C.G. Plopper and J.P. Joad. Plasticity in respiratory motor control: neuroplasticity in nucleus tractus solitarius neurons after episodic ozone exposure in infant primates. Journal of Applied Physiology 94:819-827.
2003 Evans, M.J., M.V. Fanucchi, G.L. Baker, L.S. Van Winkle, L.M. Pantel, S.J. Nishio, E.S. Schelegle, L.J. Gershwin, L.A. Miller, D.M. Hyde, P.L. Sannes and C.G. Plopper. Atypical development of the tracheal basement membrane zone of infant rhesus monkeys exposed to ozone and allergen. American Journal of Physiology: Lung Cellular and Molecular Physiology 285:L931-L939.
2003 Miller, L.A., D.M. Hyde, L.J. Gershwin, E.S. Schelegle, M.V. Fanucchi, M.J. Evans, J.E. Gerriets, L.F. Putney, M.Y. Stovall, N.K. Tyler, J.L. Usachenko and C.G. Plopper. The effect of house dust mite aeroallergen and air pollutant exposures during infancy. Chest 123 (3 Supplement):434S.
2003 Schelegle, E.S., L.A. Miller, L.J. Gershwin, M.V. Fanucchi, L.S. Van Winkle, J.E. Gerriets, W.F. Walby, V. Mitchell, B.K. Tarkington, V.J. Wong, G.L. Baker, L.M. Pantle, J.P. Joad, K.E. Pinkerton, R. Wu, M.J. Evans, D.M. Hyde and C.G. Plopper. Repeated episodes of ozone inhalation amplifies the effects of allergen sensitization and inhalation on airway immune and structural development in rhesus monkeys. Toxicology and Applied Pharmacology 191:74-85.
2004 Boland, B., Lin, C-Y, Morin, D., Miller, L., Plopper, C.G. and Buckpitt, A.: Metabolism of the cytotoxicants naphthalene and 1-nitronaphthalene in dissected airways of Rhesus macaques in a model of allergic asthma. Env. Health Persp, submitted.
2004 Evans, M.J., PL Sannes. Development of the extracellular matrix. The basement membrane zone. In: The Lung: Development, Aging and the Environment. R. Harding, K. Pinkerton, C. Plopper (Eds.) Academic Press Ltd., London, UK. pp. 74-80 .
2004 Evans MJ , MV Fanucchi, LS Van Winkle, GL Baker, LM Pantle, SJ Nishio, ES Schelegle, LJ Gershwin, LA Miller, DM Hyde and CG Plopper. The remodeled tracheal basement membrane zone of infant rhesus monkeys after six months of recovery. Clin Exptl Allergy. In press
2004 Fanucchi, M. V., C. G. Plopper. Environmental toxicants and lung development in experimental models. pp. 345-352. In: The Lung: Development, Aging and the Environment. Harding, R., K. Pinkerton, C. Plopper, (Eds). Elsevier Academic Press, London.
2004 Larson, S.D., E.S. Schelegle, W.F. Walby, L.J. Gershwin, M.V. Fanucchi, M.J. Evans, J.P. Joad, B.K. Tarkington, D.M. Hyde and C.G. Plopper. Postnatal remodeling of the neural components of the epithelial-mesenchymal trophic unit in the proximal airways of infant rhesus monkeys exposed to ozone and allergen. Toxicol & Appl Pharmacol. 194(3):211-20
2004 Tran, M-U., A Weir, M Fannuchi, A Rodriguez, L Pantle, S Smiley-Jewel, L Van Winkle, M Evans, L Miller, E Schelegle, L Gershwin, D Hyde, C Plopper. Smooth muscle hypertrophy in distal airways of sensitized infant rhesus monkeys exposed to house dust mite allergen. Clin Exp Allergy. Under Review.
